COX-2、VEGF、cyclinD1在胃癌及慢性萎缩性胃炎的表达及其意义

武春燕; 胡怀远; 马国栋; 刘岩

COX-2、VEGF、cyclinD1在胃癌及慢性萎缩性胃炎的表达及其意义

Expression and its of COX-2,VEGF and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance

摘要

摘要: 目的: 探讨COX-2、VEGF、cyclinD1蛋白在胃癌及慢性萎缩性胃炎组织中的表达及其意义。方法: 采用免疫组化法检测COX-2、VEGF、cyclinD1蛋白在60例胃癌组织和20例慢性萎缩性胃炎组织中的表达。结果: COX-2、VEGF、cyclinD1在胃癌和慢性萎缩性胃炎组织中的阳性表达率分别为66.67%、76.67%、61.67%和40.00%、35.00%、15.00%,差异均有统计学意义(P<0.005~P<0.05)。结论: COX-2、VEGF、cyclinD1蛋白的阳性表达与慢性萎缩性胃炎癌变有一定关系。

Abstract: Objective: To investigate the expression of cyclooxyenase-2(COX-2),vascular endothelial cell growth factor(VEGF) and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance.Methods: The expression of COX-2,VEGF and cyclin D1 in 60 cases of gastric carcinoma and 20 cases of chronic atrophic gastritis was studied by immunohistochemical method.Results: The positive rate of COX-2 was 66.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.05).The positive rate of VEGF was76.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.005).The positive rate of cyclin D1 was 61.67 in gastric carcinoma,which was significantly higher than that in chronic atrophic gastritis(P<0.005).Conclusions: The expression level of COX-2,VEGF and cyclin D1 may be closely correlated with the cancerous transformation process of chronic atrophic gastritis.

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