许力, 杨任民, 洪铭范. 肝豆状核变性患者的免疫功能监测[J]. 蚌埠医学院学报, 2006, 31(5): 456-458.
    引用本文: 许力, 杨任民, 洪铭范. 肝豆状核变性患者的免疫功能监测[J]. 蚌埠医学院学报, 2006, 31(5): 456-458.
    XU Li, YANG Ren-min, HONG Ming-fan. Study of the immune function in patients with hepatolenticular degeneration[J]. Journal of Bengbu Medical College, 2006, 31(5): 456-458.
    Citation: XU Li, YANG Ren-min, HONG Ming-fan. Study of the immune function in patients with hepatolenticular degeneration[J]. Journal of Bengbu Medical College, 2006, 31(5): 456-458.

    肝豆状核变性患者的免疫功能监测

    Study of the immune function in patients with hepatolenticular degeneration

    • 摘要: 目的: 了解肝豆状核变性(hepato lenticular degeneration,HLD)患者的免疫状态特点。方法: 选取正常对照组19名及HLD患者21例,散射比浊法和流式细胞术分别测定血清免疫球蛋白、补体水平及外周静脉全血T淋巴细胞亚群、CD3-CD16+CD56+、CD19+计数。结果: HLD患者体液免疫指标中CD19+、IgG、IgM均较正常组升高,C4较正常组减低(P<0.05~P<0.01);细胞免疫指标CD4+、CD4+/CD8+、CD3-CD16+CD56+均较正常组减低,CD8+升高(P<0.05~P<0.01)。结论: HLD患者的免疫状态紊乱表现为体液免疫处于亢进状态,细胞免疫低下。

       

      Abstract: Objective: To study the immunological characteristics of patients with hepatolenticular degeneration(HLD).Methods: The levels of serum immunoglobulins,complement and T-lymphocyte subsets,the indexes of the humoral immunity and the propotion of CD19+ in 21 patients with HLD and 19 normal controls were measured with immune turbidimetry and flow cytometry.Results: The levels of IgG and IgM in group HLD were increased compared with the controls,except for C4,which was depressed(P<0.05~P<0.01),together with the ratio of CD4+/CD8+,the propotion of CD3-CD16+CD56+、CD4+ increased(P<0.05~P<0.01).Conclusions: The study showed that there was disorder of the immunological state in patients with HLD,and suggests the manifestation of which is activation of the humoral immunity and depression of the cellular immunity.

       

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