Abstract: Objective: To explore the screening significance of serum pepsinogenⅠ and Ⅱ(PG Ⅰ and PG Ⅱ) in elderly patients with chronic gastritis.Methods: Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group(52 cases,over 70 years old) and young and middle-aged group(46 cases,20 to 60 years old).The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR(PGⅠ/PGⅡ) was calculated.Results: The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups(P<0.01).The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middle-aged group(P<0.01).The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98.06 μg/L,0.812 and 0.858,respectively,and the critical value of PGR,sensitivity and specificity were 6.68 μg/L,0.758 and 0.810,respectively.Conclusions: The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.