Abstract: Objective: To investigate the influence of ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG) on the apoptosis of Lewis lung cancer cell line and elucidate its possible mechanism.Methods: Lewis lung cancer cells were conventionally cultured.Cells during the stage of logarithmic growth were divided into ¹⁸F-FDG treatment group and control group.Using light microscopy,trammissional electron microscopy,flow cytometry and immunohistochemical techniques to analyse apoptosis induced by different concentrations of ¹⁸F-FDG and expressions of bcl-2 and bax genes.Results: Lewis lung cancer cell showed morphological and physiologic chemistry changes of apoptosis after exposure to ¹⁸F-FDG.Lipid peroxidation and apoptosis rate increased with the increase of the concentration of ¹⁸F-FDG.The expression of bcl-2 gene decreased and that of bax gene increased.Conclusions: ¹⁸F-FDG may induce apoptosis of Lewis lung cancer cells,and apoptosis rate increased with the increase of the concentration of ¹⁸F-FDG.