Abstract: Objective: To summarize the experience of interventional therapy for Budd-Chiari syndrome(BCS).Methods: Inferior vera cava(IVC) and hepatic vein venography were first carried out,the obliteration or stenosis in the IVC was opened or dilated with the hard tip of guide wire or puncture needle and balloon,then a stent was implanted.Results: The procedure was successful in 318 out of 359 patients including IVC intervention in 306 patients,and hepatic vein intervention in 12 patients.IVC stent was used in 232 patients and hepatic vein stent in 2 patients.There was no pulmonary embolism happened.There were liver coma in 1 patient and acute heart dysfunction in 21 patients.Two patients were combined with acute IVC thrombosis.Follow up in 248 cases ranged from 6 to 126 months.The recurrence was found in 21 patients.Conclusions: Interventional therapy for Budd-Chiari syndrome is less invasive,safe,effective,with less complications and fast recovery and it is the first choice for BCS.