Abstract: Objective: To evaluate effect and safety of edaravone on patients with brain stem hemorrhage.Methods: Forty patients with brain stem hemorrhage were devided into edaravone group(n=20) and control group(n=20).Cases of edaravone group were infused at a dose 30 mg twice a day for 14 days.The measures of osmotic diuretics,antihypertensives,antidiabetics and prevention complication were executed in the control group.The European stroke scale(ESS) and activities of daily living(ADL) were evaluated before and after treatment for judging effect and side effect.Results: There were significant differences between edaravone group and control group in ESS and ADL(P<0.01).The efficiency in treatment group was significantly higher than that in control group(P<0.01)and without complications.Conclusions: Edarvone is effective and safe drug in treating patients with acute brain stem hamorrage.