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    Skp2和Ki67在子宫颈鳞状细胞癌组织中的表达及其临床意义

    Expressions of Skp2 and Ki67 in cervical carcinoma and its clinical significance

      摘要
    • 摘要: 目的: 探讨子宫颈鳞状细胞癌组织中Skp2和Ki67的表达情况及其临床意义。方法: 采用免疫组织化学EliVision法检测60例子宫颈鳞状细胞癌组织、30例子宫颈上皮内瘤变(CIN)和30例子宫颈正常鳞状上皮组织中Skp2和Ki67的表达,分析子宫颈鳞状细胞癌形成过程中Skp2和Ki67表达的变化及其与临床病理参数的关系。结果: Skp2和Ki67在正常子宫颈、CIN和子宫颈鳞状细胞癌组织中的表达率分别为13.3%、66.7%、71.7%和16.7%、56.7%、83.3%,二者在CIN和子宫颈鳞状细胞癌中表达率均明显高于正常子宫颈组织(P<0.01);在子宫颈鳞状细胞癌组织中,Skp2和Ki67均有一定关系(P<0.05)。结论: Skp2和Ki67在子宫颈鳞状细胞癌的发生、发展过程中起重要作用。同一子宫颈鳞状细胞癌组织中Skp2和Ki67的表达有一定关系。Skp2和Ki67联合检测可作为早期诊断CIN及子宫颈鳞状细胞癌的标志物,可提高子宫颈鳞状细胞癌的早期诊断率。

       

      Abstract: Objective: To explore the expressions of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expressions of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens,including 60 cases of cervix carcinoma,30 cases of cervical intraepithelial neoplasia (CIN),and 30 cases of normal cervical epithelia.The expression changes of Skp2 and Ki67 proteins in the formation of cervical intraepithelial neoplasia and cervix carcinoma and the relationship between the clinical features and pathological features were analyzed.Results: The positive rates of Skp2 and Ki67 in normal cervical epithelia,CIN and cervix carcinoma were 13.3%,66.7%,71.7% and 16.7%,56.7%,83.3%,respectively;the positive rates of both in CIN and cervix carcinoma were notably higher than in normal cervical epithelia (P<0.01);and there had some relationship of Skp2 and Ki67 in the same cervical carcinoma tissues (P<0.05).Conclusions: Skp2 and Ki67 expressions may play an important role in the development and progression of cervical carcinoma;Skp2 and Ki67 could be used as markers for early diagnosis of cervix carcinoma.It can be helpful for increasing the ratio of early diagnosis of cervix carcinoma.

       

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