Abstract: Objective: To understand the pathogeny of and treatment for atrial fibrillation(AF).Methods: The pathogeny,type,artery embolization complications,treatment and prognosis of 150 hospitalized patients with atrial fibrillation were analyzed retrospectively.Results: Coronary heart disease ranked the first,followed by hypertension in pathogeny.Amiodarone was safe and effective for treatment of cardioversion of paroxysmal atrial fibrillation and maintenance of sinus rhythm.Conclusions: Coronary disease and hypertension are the major causes of atrial fibrillation.Analysis of the causes of atrial fibrillation is of great value for the prevention and treatment of the disease.