Abstract: Objective: To explore the clinical effects of complete video-assisted-thoracoscopic lobectomy and thoracoscopic lobectomy in the treatment of non-small cell lung cancer at early stage.Methods: The clinical data of 60 patients with non small cell lung cancer treated with lobectomy were analyzed.The patients treated with thoracoscopic lobectomy(30 cases) and complete video-assisted-thoracoscopic lobectomy(30 cases) were divided into control group(OT group) and observation group(VATS group),respectively.The patient selection,operation time,volume of intraoperative bleeding loss,number of lymph node dissection,volume of postoperative drainage,postoperative hospital stay,incidence of postoperative complication and total cost of hospitalization between two groups were compared.Results: The volume of intraoperative bleeding loss and postoperative hospital stay in VAST group were significantly less than those in OT group(P<0.05),but its total cost of hospitalization was significantly higher than that in OT group.The differences of the number of lymph node dissection,volume of postoperative drainage,operation time and incidence of postoperative complication between two groups were not statistically significant(P>0.05).Conclusions: The complete video-assisted-thoracoscopic surgery lobectomy in the treatment of non-small cell lung cancer at early stage is safe and effective,which is worthy of clinical use.