Abstract: Objective: To investigate the risk factors of diabetic nephropathy in patients with type 2 diabetes mellitus.Methods: One hundred and twenty type 2 diabetic patients were divided into type 2 diabetes mellitus group(DM group,60 cases) and diabetic nephropathy group(DN group,60 cases) according to the level 24 h urine micro albumin(UAlb).The age,course of disease,and levels of blood pressure,body mass index(BMI),fasting plasma glucose(FPG),glycosylated hemoglobin A1c(HbA1c),triglyceride(TC) and total cholesterol(TG) in all cases were observed.The correlations of DN with each factor were analyzed using multi-factor unconditioned logistic regression analysis.Results: The course of disease in DN group was longer than that in DM group(P< 0.01).Compared with DM group,the means of age,and levels of SBP,DBP and FPG in DN group were higher(P< 0.01 to P< 0.05).Logistic regression analysis showed that the course of disease,SBP,DBP,TG and TC were the independent risk factor of DN(P< 0.01).Conclusions: Age,course of disease,hyperglycaemia,hypertension and dyslipidemia are the risk factors of type 2 diabetic nephropathy.