Abstract: Objective: To compare the efficacy of totally extraperitoneal prosthesis(TEP) and open tension-free hernioplasty in inguinal hernia repair.Methods: One hundred and four patients treated with inguinal hernia repair were divided into the TEP group(46 cases) and open tension-free hernioplasty group(58 cases) according to their operation methods.The perioperative clinical parameters and recurrence rate between two groups were compared.Results: The therapeutic effects of two groups were better.The differences of the time of operation,postoperative pain,hospital stay and hospitalization expense between two groups were statistically significant(P<0.05).The differences of the blood loss and postoperative complications between two groups were not statistically significant(P>0.05).There was not recurrence in two groups after following up for 1 year.Conclusions: Both TEP and open tension-free hernioplasty in treating inguinal hernia are effective,the treatment should be selected according to patient condition.