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    急性失代偿性心力衰竭病人血miR-25、Na+水平与心力衰竭程度的关系

    Relationship between serum miR-25, Na+ levels and the degree of heart failure in patients with acute decompensated heart failure

      摘要
    • 摘要:
      目的： 探讨急性失代偿性心力衰竭（ADHF）病人血微小RNA(miR)-25、钠离子（Na+）水平及与心衰程度间关系。
      方法： 选取ADHF病人126例为研究对象，按照美国纽约心脏病学会（NYHA）心功能分级分为Ⅱ级48例、Ⅲ级43例、Ⅳ级35例。对比不同心衰程度病人血miR-25、Na+水平、低钠血症发生情况，采用Sperman秩相关分析miR-25、低钠血症及与心衰程度的相关性，并采用多元logistic回归进一步分析血miR-25、低钠血症与ADHF心衰程度间独立关系。
      结果： 不同心衰程度病人miR-25、低钠血症发生率比较，差异均有统计学意义（P ＜ 0.01），随着心衰程度增加，病人miR-25、低钠血症发生率呈增加趋势。miR-25、低钠血症发生率（rs = 0.551、0.320，P ＜ 0.01）与心衰程度呈正相关。调整混杂因素后，miR-25（OR = 3.942，95%CI：2.230～6.969, P ＜ 0.01）、低钠血症（OR = 3.889, 95%CI：2.159～7.004, P ＜ 0.01）是ADHF病人心衰程度的危险因素。
      结论： ADHF病人miR-25呈高表达，易出现低钠血症，且miR-25、低钠血症与病人病情程度独立相关。

       

      Abstract:
      Objective To investigate the relationship between blood microRNA (miR-25), Na+ levels in patients with acute decompensated heart failure (ADHF) and the degree of heart failure.
      Methods One hundred and twenty-six patients with ADHF were selected, and they were classified into 48 cases of class Ⅱ, 43 cases of class Ⅲ, and 35 cases of class Ⅳ according to the cardiac function classification of the New York Heart Association (NYHA) of the United States. The blood miR-25, Na+ levels, and the occurrence of hyponatraemia in patients with different degrees of heart failure were compared. Sperman rank correlation was used to analyze the correlation between miR-25, hyponatraemia and the degree of heart failure. Multivariate logistic regression was used to further analyze the independent relationship between blood miR-25, hyponatraemia and degree of heart failure in ADHF.
      Results The comparison of miR-25 and incidence of hyponatraemia in patients with different degrees of heart failure showed statistically significant differences (P ＜ 0.01), and with the increase of the degree of heart failure, the miR-25 and incidence of hyponatraemia in patients showed an increasing trend. The miR-25 and incidence of hyponatraemia were positively correlated with the degree of heart failure (rs = 0.551, 0.320, P ＜ 0.01). After adjusting for confounders, miR-25 (OR = 3.942 95%CI: 2.230–6.969, P ＜ 0.01), and hyponatraemia (OR = 3.889, 95%CI: 2.159–7.004, P ＜ 0.01) were risk factors for the degree of heart failure in patients with ADHF.
      Conclusion ADHF patients show high expression of miR-25 and they are prone to hyponatremia. The miR-25 and hyponatremia are independently correlated with the severity of patients' disease.

       

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