Abstract: Objective: To evaluate the efficacy of uterine artery infusion chemotherapy on trophoblastic tumor.Methods: Thirty-three patients were randomly divided into two groups.One group were treated by uterial infusion chemotherapy and the other received venous chemotherapy.The therapeutic effects and the toxic and side effects of the two groups were analyzed and compared.Results: The rate of myelosuppression in the arterial interventional group was lower than that in the venous chemotherapy group(P=0.050 to P=0.009).The carcinoma size reduced and the level of serum β-hCG decreased obviously in the arterial interventional group compared with the chemotherapy group(P=0.013,P=0.027).Conclusions: The uterine arterial infusion chemotherapy is effective for trophoblastic tumor and the toxic and side effects are smaller than that by venous chemotherapy.