Abstract: Objective: To explore the expression of survivin and p53 in epithelial borderline ovarian tumors and their clinical significance and correlation. Methods: Immunohistochemical EliVision method was used to detect the expression of survivin and p53 in 30 cases of epithelial ovarian carcinomas,30 cases of epithelial borderline ovarian tumors and 30 cases of epithelial ovarian benign tumors. Results: In epithelial benign ovarian tumors,epithelial borderline ovarian tumors and epithelial ovarian carcinomas,the positive rates of survivin immunostaining were 13.33%,43.33% and 86.67%,respectively;there were significant differences among the three groups (P < 0.05). The positive rates of p53 were 23.33%,36.67% and 73.33%,respectively;there was statistical difference between the epithelial ovarian carcinomas and the epithelial benign or borderline ovarian tumors (P < 0.05-P < 0.01),but no statistical difference was observed between the benign ovarian tumors and the borderline ovarian tumors (P > 0.05). There was a positive correlation between the expression of survivin and p53 in borderline ovarian tumors (P < 0.05). Conclusions: Over expression of survivin and p53 suggests that they may participate in the oncogensis and progression of epithelial borderline ovarian tumors,which can provide reference for the diagnosis and prognosis of the epithelial borderline ovarian tumors. Both survivin and p53 may play an important role in the pathogenesis of epithelial borderline ovarian tumors.