Abstract: Objective: To observe the efficacy of early interference treatment for hand-foot-and-mouth disease with small doses methylprednisolone.Methods: One thousand eight hundred hand-foot-and-mouth disease patients were randomly divided into two groups.The treatment group (n=950) was treated with symptomatic treatment and intravenous drip treatment with methylprednisolone 1-2 mg·kg^-1·d^-1,the control group (n=850) was treated with symptomatic treatment and conventional treatment for abatement of fever.To investigate the therapeutic effect of the two groups of clinical treatment.Results: The treatment efficacy in the treatment group was higher than in the control group (P<0.01),comparing the time to allaying a fever,stopping body shaking,stopping frightened during sleep in two groups.Conclusions: The therapeutic effect in the treatment group with small doses of methylprednisolone early interference treatment was superiorer than in the control group with conventional symptomatic treatment,it was well worth clinical popularizing and application.