Abstract: Objective: To explore the prevention about complications of pituitary adenomas microsurgery and improve the surgery skills. Methods: The clinical data of 12 patients whose pituitary adenomas were resected and accompanied with complications were analyzed respectively. Results: Nine cases were accompanied with insipidus after operation,among them,8 cases were accompanied with acute insipidus,and 1 case with delayed insipidus. One case was with cerebral salt wasting syndrome,2 cases with cerebrospinal rhinorrhea,3 cases with hemorrhage,1 case with visual disturbance,1 case with intracranial infection,2 cases with infarction in frontal lobe and hypothalamus,and 1 case was died. Conclusions: Familiarizing the anatomy of spheniodal sinus,improving the microsurgery skills and treating correctly are all important to decrease the postoperative complications.