Abstract: Objective: To observe the effect of recombinant human epidermal growth factor in repair of cleft palate.Methods: Sixty patients were divided into two groups,one with 30 patients using recombinant human epidermal growth factor as experimental group and the other 30 patients as control group.All the patients were observed on several aspects such as healing situation of wound surface,persistence time of ache,recovery of normal diet,the changes in temperature and the weight.Results: Compared with control group,experimental group had the shorter persistence time of red swelling of the raw surface and of ache(P<0.001),the faster recovery of normal diet and the lower of decrease in weigh(P<0.001).But the changes in temperature were not different in the two groups(P>0.05).Conclusions: The recombinant human epidermal growth factor can facilitate the wound healing.The application of recombinant human epidermal growth factor in palatoplasty is beneficial to the patients.