Abstract: Objective: examing the methods employed in surgical treatment aiming at curing refractory epilepsy by intervening and the effects such methods intend to achieve. Methods: On the basis of the relative data concerning 65 patients with refractory epilepsy collected through the means of electroencephalogram or EEG,video EEG,CT,single photon emission computed tomography or SPECT, magnetic resonance imaging or MRI,and through assessing their cognitive capacity before their treatments,6 methods were employed respectively. These methods are:resecting the affected area,degenerative brain tissues,and anterior temple lobe,removing hippocampus apricot kernel in a selective way, transecting callosotomy, and craniostenosis restitution opration while using the means of multiple subpial transection(hereafter referred to as MST) in actual operation(the method was employed in one case); resecting affected area and denaturation constitution degenerative brain tissues while using the means of MST and heat treatment in operations(the method was employed in 36 cases); making use of the means MST combined with heat treatment while transecting callosotomy in a selective way in operations(the method was employed in 5 cases);; radiate treatment on both hippocampus apricot kernel combined with the means of MST and heat treatment (the method was employed in 1 case); resecting affected area and denaturation constitution, transecting callosotomy in a selective way combined with the means of MST (the method was employed in 4 cases); resecting affected area, denaturation constitution,anterior temple lobe and hippocampus apricot kernel while using MST (the method was employed in 18 cases). Results: After relative treatments patients were followed up with the length of the follow-up ranging from 6 months to 11 years and judged by the Engel standard 26 of them could reach the level of Ⅰ,and 9 of them could reach the level of Ⅱ,all recovering completely; besides,20 of those patients could reach the level of Ⅲ,recovering well,and 6 of those patient who were followed up could reach the level of Ⅳ,which suggests that the ratio for total recovery could reach to 60.00% and the ratio for ideal recovery could amount to 90.77% and all those patients have demonstrated the sigh of getting better in terms of their intelligence. Conclusions: When dealing with refractory epilepsy concerning multiple focus of refractory epilepsy in surgical treatment,ideal and effective results could realized by employing appropriate but different surgical methods based on the different areas in epilepsy electroencephalogram.