Abstract: Objective: To evaluate hysteroscopy combined with laparoscopy in diagnosis and treatment of infertility. Methods: Fortyeight patients with infertility underwent hysteroscopy and laparoscopic operation; their etiological factors were diagnosed and pertinently treated. Results: Abnormity was detected in 97.92% of the patient (47/48). Among them, chronic pelvic inflammatory disease accounted for 31 cases,endometriosis 8 cases,polycystic ovarian syndrome 3 cases,endometrial polyps 2 cases,mediastinum uterus 1 case,intrauterine adhesion 1 case and benign ovarian tumors 1 case. No complications caused by hysteroscopy combined with laparoscopy were found. The pregnancy rate was 48.5% after 3 years. Conclusions: The procedure of combined laparoscopy and hysteroscopy has great value in diagnosis and treatment of the infertility.