脑梗死急性期血清白介素-6的变化及其临床意义

Change of serum interleukin-6 in patients with acute cerebral infarction and its significance

摘要: 目的:探讨急性脑梗死患者血清白介素-6(IL-6)水平的变化及其与脑梗死严重程度的关系。方法:测定63例急性脑梗死患者和24名健康人的血清IL-6的含量,按脑卒中患者临床神经功能缺损程度评分(NDS)标准对患者进行评分,分组比较。结果:脑梗死组血清IL-6水平明显高于正常对照组(P<0.01)。脑梗死重型组血清IL-6水平明显高于中型、轻型组(P<0.01)。结论:血清IL-6水平增高与脑梗死的发生和严重程度有密切关系。

Abstract: Objective: To investigate the relations between the serum level of interleukin-6(IL-6) and the severity of acute cerebral infarction.Methods: The serum level of IL-6 in 63 patients with acute cerebral infarction and 24 healthy persons was determined.All the patients were scored by clinic neurological function deficit scale(NDS),and comparision was made between the groups.Results: The serum level of IL-6 of the patients was significantly higher than that of the normal control(P<0.01),and the serum level of IL-6 of the group with serious cerebral infarction was significantly higher than the groups with middle and mild cerebral infarction(P<0.01).Conclusions: The serum level of IL-6 is closely correlated with the severity of cerebral infarction.