细胞色素P450 1A1基因Ile/Val多态性与子宫颈癌的遗传易感性研究

Research of cytochrome P450 1A1 Ile/Val polymorphism and genetic susceptibility in cervical cancer

摘要: 目的:探讨细胞色素P4501A1(CYP1A1)基因Ile/Val多态性与子宫颈癌遗传易感性的关系。方法:采用等位基因特异性PCR(as-PCR)分析技术,检测92例子宫颈鳞状细胞癌患者、31例子宫颈腺癌患者和100例对照组CYP1A1基因Ile/Val多态性。结果:对照组3种基因型Ile/Ile、Ile/Val、Val/Val频率分别为33.0%、64.0%和3.0%,子宫颈鳞状细胞癌组分别为20.7%、68.0%和16.3%,子宫颈腺癌组分别为12.9%、67.7%和19.4%;组间比较差异有统计学意义(P<0.05)。结论:CYP1A1基因Ile/Val多态性与子宫颈癌有遗传易感性。

Abstract: Objective: To elvaluate the relationship between the genetic polymorphism of cytochrome P450 1A1 (CYP1A1) and the genetic susceptibility in cervical cancer.Methods: The distribution frequencies of CYP1A1 Ile/Val polymorphism were detected in 92 cervical squamous cell carcinoma,31 cervical adenocarcinoma and 100 healthy controls by allele-specific PCR.Results: The frequencies of three genotypes Ile/Ile,Ile/Val,Val/Val were 33.0%,64.0% and 3.0% respectively in control group;20.7%,68.0% and 16.3% respectively in cervical squamous cell carcinoma;and 12.9%,67.7% and 19.4% respectively in cervical adenocarcinoma.There was the significant difference among the three groups (P<0.05).Conclusions: Polymorphism of CYP1A1 Ile/Val plays an important role in the oncogenesis of cervical cancer.