Abstract: Objective: To explore the clinical value of cervical conization in treatment of cervical intraepithelial neoplasia(CIN) and stage Ⅰa₁ of cervical cancer,and the measures to prevent complication.Methods: Ninety-nine cases of CIN 2-3 and cervical cancer Ⅰa₁ were treated by cold knife conization(CKC) or electric knife conization.The surgical effect,complication and correlative factors were analyzed.Results: CIN 2 was altered to CIN 3 in 6 of the 30 cases(20%) after cervical conization,and CIN 3 accompanied by early invasive cervical cancer were observed in 6 of the 67 cases(8.96%) after cervical conization.The pathological examination results before and after cervical conization were in conformity in 72 of the 99 cases(72.73%).There was no recurrence after single cervical conization.The occurrence of postoperative bleeding was 18.48% in the early stage and 9.78% in the late stage,and the infection rate was 4.34%(4/92).The postoperative cyesis rate was 44.0%.Conclusions: There is still obvious difference between the pathological diagnosis after cervical conization and multiple biopsy diagnosis before operaion.For the CIN 2 patients with large extent of disease or uncertain diagnosis by colposcope,cervical conization can not only help to confirm the diagnosis,but remove the focus completely.It is also a safe and effecive therapy for CIN 3 patients who yearn to have children.The surgical complication could be prevented by surgical skills.