Abstract: Objective:To explore the correlation between the levels of soluble E-selectin (SES),interleukin-10 (IL-10) and the degree of coronary artery stenosis in acute coronary syndrome (ACS).Methods:Ninety-four patients receiving coronery artery angiography were divided into ACS group (39 cases),stable angina pectoris (SAP) group (23 cases) and control group (32 cases).The serum levels of SES and IL-10 were measured by ELISA,and the high-sensitive creactive protein (hs-CRP) was dertermined by immunoturbidimetry.Results:The serum levels of SES and hs-CRP in ACS group were significantly higher than those in SAP group and control group (P<0.01);the serum levels of SES and hs-CRP in SAP group had no significant difference compared with those of the control (P<0.05).SES and IL-10 had no obvious correlation with the count of coronary athey stenosis or the degree of coronary artery stenosis (P>0.05).Conclusions:Increased serum levels of SES and IL-10 may reflect the instability of atherosclerotic plaques but not the degree of coronary artery stenosis in acute coronary syndrome.