Abstract: Objective: To investigate the surveillance data of bacterial resistance in Lu'an city hospitals in 2008.Methods: Bacterial susceptibility experiments were performed on 102 samples clinically collected from 3 hospitals in Lu'an city,using routine custom dilution MIC method according to the CLSI(2008) guidelines;the resistance,intermediate and susceptible rates of the bacteria to antimicrobial agents were measured.Results: Among the 102 bacteria samples,Escherichia coli accounted for 27,Acinetobacter baumannii 25,Pseudomonas aeruginosa 23,Klebsiella 18,Stenotrophomonas maltophilia 7 and others 2.Carbapenems were the most effective antimicrobial agents against Gram-negative bacilli,and other effective ones were piperacillin-tazobactam(73.5%),amikacin(67.6%) and fosfomycin(62.7%).Gram-negative bacilli showed high resistance to ampicillin(96.1%),cefoxitin(83.3%) and aztreonam(81.4%),and were also noticeably resistant to cefoperazone/sulbactam(51.0%) and cefepime(39.4%).Conclusions: We should administer antimicrobial drugs according to the "Guiding principles for the clinical use of antibacterial drugs",and rationally choose antimicrobial agents in treatment of bacterial infections to control the bacterial resistance rates.