奥沙利铂联合亚叶酸钙、氟尿嘧啶治疗晚期胃癌

Oxaliplatin in combination with calcium folinate and fluorouracil for treatment of advanced gastric cancer

摘要: 目的: 评价奥沙利铂联合氟尿嘧啶(5-Fu)、亚叶酸钙(CF)治疗晚期胃癌的疗效及安全性。方法: 奥沙利铂(OXA)130mg/m²,静脉滴注(静滴)2 h,第1天;亚叶酸钙200 mg静滴1 h,第1~5天;5-Fu 350 mg/m²静滴4 h,第1~5天;每3周重复一周期,连用2周期后评价疗效。结果: 观察28例,其中CR 1例,PR 11例,SD 10例,PD 6例,总有效率42.9%。主要不良反应为白细胞下降、恶心呕吐及周围神经毒性。结论: 奥沙利铂联合化疗治疗晚期胃癌疗效较好,且不良反应小。

Abstract: Objective: To evaluate the effect and safety of oxaliplatin(OXA) combined with calcium folinate(CF) and fluorouracil(5-Fu) regimen for patients with advanced gastric cancer.Methods: OXA 130 mg/m² (2 hours infusion on the first day),CF 200 mg/m² (1 hour infusion for 5 days) and 5-Fu 350 mg/m²(4 hours infusion on the first day) were administered and the regimen was repeated every 3 weeks.The efficacy was evaluated after two repeated cycles were completed.Results: Twenty-eight patients were included in the study.One patient achieved CR,11 PR,10 SD and 6 PD.The overall response rate was 42.9%.The main adverse effects were bone marrow suppression,nausea,vomiting and neurosensory toxicity.Conclusions: OXA-CF-5-Fu regimen is highly effective for treatment of advanced gastric cancer with mild toxicity.