ObjectiveTo explore the effects of different doses of low-molecular-weight heparin (LMWH) on the pulmonary infection, digestive system bleeding and incidence of cardiovascular and cerebrovascular events, analyze the correlation between the dose of heparin and clinical indicators, and provide theoretical basis for guiding the individualized use of LMWH in maintenance hemodialysis patients.

MethodsThe correlation between the dose of heparin and clinical indicators in 108 patients treated with maintenance hemodialysis was analyzed using the single-center cross-section study.The patients were divided into the low-dose group (treatment with the dosage of LMWH < 40 IU/kg) and high-dose group (treatment with the dosage of LMWH ≥40 IU/kg).The differences of the pulmonary infection, bleeding of digestive system, incidence of cardiovascular and cerebrovascular events, and clinical indicators were compared between two groups.

ResultsThe results of Pearson correlation analysis showed that the LMWH dosage per unit body mass was positively correlated with hemoglobin level (r=0.213, P < 0.05), and the LMWH dosage was negatily correlatied with erythropoietin in patients treated with maintenance hemodialysis (r=-0.225, P < 0.05).There was no statistical significance in the incidence rates of pulmonary infection, digestive system bleeding, and cardiovascular and cerebrovascular events between two groups (P>0.05).The levels of ferritin and transferrin saturation in low-dose group were greater than those in high-dose group (P < .01), and the differences of other clinical indicators between two groups were not statistically significant (P>0.05).

ConclusionsThe dose of LMWH has no significantly impact on the risks of pulmonary infection, digestive system bleeding and cardiovascular and cerebrovascular events.The greater the hemoglobin usage is, the higher the hemoglobin levels and the lower the erythrotropin dose are.