高级检索
    卢朋松, 倪鹏, 赵飞龙, 潘浩斌, 董向梅. 纳米银敷料联合表皮生长因子凝胶制剂对深Ⅱ度烧伤创面溶痂及愈合的影响[J]. 蚌埠医科大学学报, 2020, 45(7): 902-905, 909. DOI: 10.13898/j.cnki.issn.1000-2020.07.016
    引用本文: 卢朋松, 倪鹏, 赵飞龙, 潘浩斌, 董向梅. 纳米银敷料联合表皮生长因子凝胶制剂对深Ⅱ度烧伤创面溶痂及愈合的影响[J]. 蚌埠医科大学学报, 2020, 45(7): 902-905, 909. DOI: 10.13898/j.cnki.issn.1000-2020.07.016
    shu
    LU Peng-song, NI Peng, ZHAO Fei-long, PAN Hao-bin, DONG Xiang-mei. Effect of nanometer silver dressing combined with epidermal growth factor gel on the wound dissolved scab and healing of deep Ⅱ degree burn[J]. Journal of Bengbu Medical University, 2020, 45(7): 902-905, 909. DOI: 10.13898/j.cnki.issn.1000-2020.07.016
    Citation: LU Peng-song, NI Peng, ZHAO Fei-long, PAN Hao-bin, DONG Xiang-mei. Effect of nanometer silver dressing combined with epidermal growth factor gel on the wound dissolved scab and healing of deep Ⅱ degree burn[J]. Journal of Bengbu Medical University, 2020, 45(7): 902-905, 909. DOI: 10.13898/j.cnki.issn.1000-2020.07.016
    shu

    纳米银敷料联合表皮生长因子凝胶制剂对深Ⅱ度烧伤创面溶痂及愈合的影响

    Effect of nanometer silver dressing combined with epidermal growth factor gel on the wound dissolved scab and healing of deep Ⅱ degree burn

      摘要
    • 摘要:
      目的 分析纳米银敷料联合表皮生长因子凝胶制剂在深Ⅱ度烧伤创面治疗中的应用效果。
      方法 按随机数字表法将156例深Ⅱ度烧伤病人分为观察组与对照组，各78例。观察组病人清创后给予纳米银敷料联合表皮生长因子凝胶制剂治疗，对照组病人清创后给予表皮生长因子凝胶制剂治疗。换药时观察创面情况。比较2组病人治疗前、治疗后1周创面视觉模拟评分（VAS）、治疗1周、2周、3周、4周创面溶痂率、细菌培养阳性率及完全溶痂时间、创面愈合时间，治疗前、治疗2周通过免疫组织化学法测定基质金属蛋白酶（MMP）-1、MMP-2表达，并记录治疗前后相关不良反应发生情况。
      结果 观察组治疗4 d创面痂皮变软，6 d大部分痂壳脱落，8 d创面痂皮基本溶解；对照组治疗4 d创面干痂形成，6 d创面干燥，部分坏死组织呈黄黑色，但尚未脱落，8 d干痂逐渐软化，10 d干痂逐渐脱落，基底肉芽组织生长。治疗后2组VAS评分明显低于治疗前（P < 0.01），且观察组明显低于对照组（P < 0.01）。观察组治疗1周、2周创面溶痂率均明显高于对照组（P < 0.01）。观察组完全溶痂时间、创面愈合时间均明显短于对照组（P < 0.01）。观察组创面细菌阳性率为11.54%，低于对照组的24.36%（P < 0.05）。与治疗前比较，治疗2周2组病人MMP-1、MMP-2表达水平均明显下降，且观察组均明显低于对照组（P < 0.01）。
      结论 纳米银敷料联合表皮生长因子凝胶制剂治疗深Ⅱ度烧伤创面溶痂率高，创面愈合时间较短，其机制可能与抑制创面MMP-1、MMP-2表达相关。

       

      Abstract:
      Objective To analyze the effects of nanometer silver dressing combined with epidermal growth factor gel on the wound treatment of deep Ⅱ degree burn.
      Methods One hundred and fifty-six patients with deep Ⅱ degree burn were randomly divided into the observation group and control group by digital table method (78 cases in each group).After the debridement, the observation group was treated with nanometer silver dressing combined with epidermal growth factor gel, and the control group was treated with epidermal growth factor gel.The wound surface condition was observed at changing the dressing.The visual analogue scale (VAS) of wound before and after 1 week of treatment, scab solubility of wound surface after 1, 2, 3 and 4 weeks of treatment, positive rate of bacterial culture, time of completing dissolution and healing time of wound were compared between two groups.The expression levels of matrix metalloproteinase-1 and 2 (MMP-1 and MMP-2) in two groups before and after 2 weeks of treatment were detected using immunohistochemistry.The incidence rates of adverse reactions before and after treatment were recorded.
      Results In the observation group, the wound scab skin became soft on the 4th day, most of the scab shell fell off on the 6th day, and the wound scab skin basically dissolved on the 8th day.In the control group, the dry scab wound formed on the 4th day, the wound became dry on the 6th day, some necrotic tissues were yellowish black, but not yet shed, the dry scab gradually softened on the 8th day, and the dry scab gradually fell off and basal granulation tissue grew on the 10th day.After treatment, the VAS scores in two groups were significantly lower than that before treatment (P < 0.01), and which in observation group was significantly lower than that in control group (P < 0.01).The wound dissolving rates in observation group at 1 and 2 weeks after treatment were significantly higher than that in control group (P < 0.01).The dissolution time and wound healing time in observation group were significantly shorter than those in control group (P < 0.01).The positive rate of bacteria in observation group (11.54%) was significantly lower than that in control group (24.36%) (P < 0.05).Compared with before treatment, the expression levels of MMP-1 and MMP-2 in two groups significantly decreased, and which in observation group were significantly lower than those in control group (P < 0.01).
      Conclusion The nanometer silver dressing combined with epidermal growth factor gel in the treatment of the wound of deep Ⅱ degree burn has high dissolving rate of scab and short wound healing time, the mechanism of which may be related to the expression inhibition of MMP-1 and MMP-2 in wounds.

       

      • HTML全文
      • 参考文献(20)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回