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    王利平, 王启之, 邓敏, 燕善军, 汪强武, 李大鹏, 汪建超. 微小RNA-100在胃癌中的表达及临床意义[J]. 蚌埠医科大学学报, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
    引用本文: 王利平, 王启之, 邓敏, 燕善军, 汪强武, 李大鹏, 汪建超. 微小RNA-100在胃癌中的表达及临床意义[J]. 蚌埠医科大学学报, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
    shu
    WANG Li-ping, WANG Qi-zhi, DENG Min, YAN Shan-jun, WANG Qiang-wu, LI Da-peng, WANG Jian-chao. The expression of microRNA-100 in gastric cancer and its clinical significance[J]. Journal of Bengbu Medical University, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
    Citation: WANG Li-ping, WANG Qi-zhi, DENG Min, YAN Shan-jun, WANG Qiang-wu, LI Da-peng, WANG Jian-chao. The expression of microRNA-100 in gastric cancer and its clinical significance[J]. Journal of Bengbu Medical University, 2015, 40(1): 37-39,42. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.012
    shu

    微小RNA-100在胃癌中的表达及临床意义

    The expression of microRNA-100 in gastric cancer and its clinical significance

      摘要
    • 摘要: 目的:探讨微小RNA-100(microRNA-100,miRNA-100)在胃癌患者组织中的表达及其与临床病理特征之间的关系.方法:提取50例胃癌及其癌旁非肿瘤组织标本的总RNA,采用TaqMan探针实时荧光定量PCR方法检测miRNA-100的表达量;并分析其与肿瘤分化程度、淋巴结转移等临床病理学特征的关系.结果:胃癌及配对癌旁非肿瘤组织中miRNA-100的相对表达量分别为1.31±0.69和0.74±0.36,差异有统计学意义(P<0.01).胃癌组织中miRNA-100的表达在年龄、性别、肿块大小、肿块位置、分化程度、淋巴结转移以及TNM分期中差异均无统计学意义(P>0.05).结论:miRNA-100在胃癌中的异常表达可能与胃癌的发生有关.

       

      Abstract: Objective:To detect the expression of microRNA-100(miRNA-100) in gastric cancer and its relation with clinicopathologic features.Methods:The total RNA in 50 gastric cancer tissue specimens and non-tumor adjacent tissue specimens were extracted, the expression levels of miRNA-100 were detected by TaqMan real-time quantitative PCR assay.The correlations of miRNA-100 expression and differentiation and lymph node metastasis of gastric cancer were analyzed.Results:The expression levels of miRNA-100 in gastric carcinoma tissue and normal gastric tissue were 1.31±0.69 and 0.74±0.36, respectively, the difference of which was statistical significance(P<0.01).The differences of miRNA-100 expressions in age, gender, tumor location, tumor size, degree of differentiation, lymph node metastasis and TNM staging were not statistically significant(P>0.05).Conclusions:The abnormal expression of miRNA-100 may be associated with the occurrence of gastric cancer.

       

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