陈国栋, 储照虎. 急性脑卒中患者抑郁发生情况及相关因素研究[J]. 蚌埠医学院学报, 2015, 40(1): 43-46. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.014
    引用本文: 陈国栋, 储照虎. 急性脑卒中患者抑郁发生情况及相关因素研究[J]. 蚌埠医学院学报, 2015, 40(1): 43-46. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.014
    CHEN Guo-dong, CHU Zhao-hu. Depression in patients with acute stroke and the related factors[J]. Journal of Bengbu Medical College, 2015, 40(1): 43-46. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.014
    Citation: CHEN Guo-dong, CHU Zhao-hu. Depression in patients with acute stroke and the related factors[J]. Journal of Bengbu Medical College, 2015, 40(1): 43-46. DOI: 10.13898/j.cnki.issn.1000-2200.2015.01.014

    急性脑卒中患者抑郁发生情况及相关因素研究

    Depression in patients with acute stroke and the related factors

    • 摘要: 目的:探讨急性期脑卒中后抑郁(PSD)的患病率及其相关危险因素,为早期诊断、早期治疗提供临床依据.方法:采用病例-对照研究方法,选择急性期脑卒中患者102例作为研究对象.收集患者常规资料包括一般情况调查、既往病史、头颅CT或MRI检查.在患者发病第14~28天内,按照中国精神障碍类与诊断标准第3版抑郁症诊断标准及Hamilton抑郁量表评分,将患者分为抑郁组和对照组.神经功能缺损程度评分采用美国国立卫生院卒中量表(NIHSS),并采用日常生活活动量表(ADL)评分评估生活能力.结果:102例患者合并PSD 46例,发生率45.09%;PSD的发生在脑卒中的性质和病灶构成部位差异均无统计学意义(P>0.05);PSD的发生率在糖尿病、高血压、冠心病和高脂血症伴发疾病差异均无统计学意义(P>0.05),但PSD患者合并症≥2种者高于对照组(P<0.05);NIHSS评分和ADL评分与PSD发生均有明显关系(P<0.01),ADL评分高是 PSD的保护因素.结论:PSD在脑卒中患者中发生率高,是脑卒中患者常见且严重的并发症;PSD与脑卒中的部位和性质均无明显关系,但与神经功能缺损和日常活动能力均有明显关系.PSD发生率与合并多种脑血管危险因素有关.

       

      Abstract: Objective:To investigate the prevalence of post stroke depression(PSD) at stroke acute phase and the related risk factors, and to provide clinical evidence for early diagnosis and treatment of it.Methods:Case-control study was used.102 patients of stroke were collected.The necessary conventional data including socio-demographic, medical history, blood, computed tomography(CT) or magnetic resonance imaging(MRI) scan examination were obtained.The patients were assessed 2 to 4weeks after the onset of stroke and divided into PSD group or control group according to the diagnostic criteria of depression in CCMD-3 of Chinese and the Hamilton Depression Rating Scale.The neurological deficit was estimated by National Institutes of Health Stroke Scale(NIHSS).The daily life skills were assessed by activities of daily living scales(ADL).Results:Of the 102 patients investigated, depressive disorder occurred in 45.09% of the cases(n=46).It was not related to the nature or location of the stroke, and there was no statistically significant difference between patients with diabetes, hypertension, coronary heart disease or hyperlipidemia(P>0.05), but patients with ≥2 complications were more susceptible to PSD(P<0.05).The score of NIHSS and ADL was consistently associated with the incidence of depression(P<0.01) and the score of ADL protection factors of PSD.Conclusions:Depression is a frequent and common complication among patients with stroke.The incident of PSD is not related with the nature or location of stroke, but obviously related to ADL and NIHSS.PSD may be associated with the risk factors for cerebrovascular diseases and complications.

       

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