颈动脉粥样硬化斑块稳定性相关因素分析

王小凤; 王辉

doi:10.13898/j.cnki.issn.1000-2200.2015.01.015

颈动脉粥样硬化斑块稳定性相关因素分析

王小凤,
王辉

Analysis of the related factors of the carotid atherosclerotic plaque stability

摘要

摘要: 目的:研究颈动脉粥样硬化斑块稳定性的危险因素.方法:分析84例存在颈动脉斑块的住院患者,根据颈动脉超声检查结果将患者分为不稳定斑块组(31例)和稳定性斑块组(53例),比较2组患者C反应蛋白(CRP)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)、胱抑素C(CyC)等危险因素,并分析上述因素与斑块稳定性的关系.结果:不稳定斑块组Hcy、CyC、CRP和LDL-C水平均高于稳定斑块组(P<0.05～P<0.01);二元logistic回归分析显示CRP、Hcy、CyC均为颈动脉粥样硬化斑块不稳定的危险因素(P<0.05).结论:CRP、Hcy、CyC是影响动脉粥样硬化斑块稳定性的重要危险因素.

Abstract: Objective:To investigate the risk factors of the carotid atherosclerotic plaque stability.Methods:Eighty-four patients with carotid plaque were divided into the unstable plaque group(31 cases) and stable plaque group(53 cases) according to the results of carotid artery ultrasound.The relationships between the risk factors of C-reactive protein(CRP), low density lipoprotein cholesterol(LDL-C), homocysteine(Hcy) and Cystatin C(CyC), and plaque stability in two groups were compared.Results:The levels of CRP, LDC-C, Hcy and CyC in unstable plaque group were higher than that in stable plaque group(P<0.05 to P<0.01).Logistic regression analysis showed that the CRP, LDC-C, Hcy and CyC were the risk factors of the carotid atherosclerotic plaque stability(P<0.05).Conclusions:The CRP, LDC-C, Hcy and CyC were the important risk factors of the carotid atherosclerotic plaque stability.

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