Abstract: Objective:To investigate the effects of the sufentanil and flurbiprofen anesthesia on the cognitive function and analgesia in elderly patients after hip arthroplasty.Methods:One hundred and twenty patients treated with hip arthroplasty were divided into the flurbiprofen combined with sufentanil analgesia group(group A) and sufentanil analgesia group(group B) according to random number table(60 cases each group).Group A were treated with 100 mg of flurbiprofen combined with 2.0 mg of sufentanil, diluting to 200 ml, patient-controlled analgesia(PCIA) for 2 ml/30 min.Group B were treated with 2.0 mg of sufentanil, diluting to 200 ml, PCIA for 2 ml/30 min.The analgesic effects in two groups were scored using visual analog scale(VAS) after 3 h, 6 h, 12 h and 24 h of operation.The cognitive function in two groups were assessed using mini-mental state examination(MMSE) before operation and after 1 d, 3 d and 5 d of operation.The sufentanil dosage, PCIA times and complications of two groups were recorded after 1 h, 24 h and 48 h of operation.Results:The VAS scores in group A after 3 h, 6 h, 12 h and 24 h of operation were significantly lower than those in group B(P<0.01).The MMSE scores in group A after 1 d, 3 d and 5 d of operation were higher than those in group B(P<0.05 to P<0.01).The sufentanil dosage and PCIA times in group A after 1 h and 24 h of operation were less than those in group B(P<0.01).The incidence rates of nausea and vomiting, restlessness, respiratory depression and cognitive dysfunction in group A were significantly lower than those in group B(P<0.05).Conclusions:The flurbiprofen analgesia can effectively reduce the incidence of cognitive dysfunction and postoperative PCIA sufentanil usage, and improve sedation analgesia.