Abstract: Objective:To identify the correlations of between the levels of plasma glucose, blood cholesterol, tumor necrosis factor-α(TNF-α) and adiponectin(APN) and traditional chinese medicine syndromes in prediabetes.Methods:The levels of fasting plasma glucose(FPG), 2-hour plasma glucose(2 hPG), triglyceride(TG), total cholesterol(TCH), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), TNF-α and adiponectin in 90 prediabetes patients with phlegm of Qi stagnation, dampness of spleen deficiency and Qi stagnation of Yin deficiency syndrome(30 cases each syndrome) and 20 healthy people(the control group) were detected.Results:Compared with the normal control group, the levels of FPG, TG and TCH and TNF-α increased, and the level of APN decreased in three syndromes patients, the differences of the levels of FPG and 2 hPG between three syndromes patients were not statistically significant(P>0.05).The levels of TG and TCH were the most significant(P<0.05), but the difference between and LDL-C was not statistically significant in phlegm of Qi stagnation patients(P>0.05).The differences of the levels of TNF-α and APN between three syndromes patients were statistically significant(P<0.05 to P<0.01).Conclusions:There are certain correlations between the levels of TCH, TG, TNF-α and APN and traditional chinese medicine syndromes in prediabetes, especial for in phlegm of Qi stagnation syndrome patients, which can provide a reference in identifying different syndromes in prediabetes.