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    张露, 郑荣生, 汪子书, 王俊斌, 杨燕. 三阴性乳腺癌90例临床特征及生存情况分析[J]. 蚌埠医科大学学报, 2015, 40(4): 434-439. DOI: 10.13898/j.cnki.issn.1000-2200.2015.04.005
    引用本文: 张露, 郑荣生, 汪子书, 王俊斌, 杨燕. 三阴性乳腺癌90例临床特征及生存情况分析[J]. 蚌埠医科大学学报, 2015, 40(4): 434-439. DOI: 10.13898/j.cnki.issn.1000-2200.2015.04.005
    shu
    ZHANG Lu, ZHENG Rong-sheng, WANG Zi-shu, WANG Jun-bin, YANG Yan. Clinical characteristics and survival analysis of triple-negative breast cancer in 90 cases[J]. Journal of Bengbu Medical University, 2015, 40(4): 434-439. DOI: 10.13898/j.cnki.issn.1000-2200.2015.04.005
    Citation: ZHANG Lu, ZHENG Rong-sheng, WANG Zi-shu, WANG Jun-bin, YANG Yan. Clinical characteristics and survival analysis of triple-negative breast cancer in 90 cases[J]. Journal of Bengbu Medical University, 2015, 40(4): 434-439. DOI: 10.13898/j.cnki.issn.1000-2200.2015.04.005
    shu

    三阴性乳腺癌90例临床特征及生存情况分析

    Clinical characteristics and survival analysis of triple-negative breast cancer in 90 cases

      摘要
    • 摘要: 目的:分析90例三阴性乳腺癌(TNBC)患者的临床资料,探讨其临床病理特征及影响预后的因素。方法:收集284例经病理科证实的乳腺癌患者的完整临床资料,应用统计学软件回顾性分析TNBC患者的临床病理特征、生存情况及肿瘤复发转移的方式。结果:284例乳腺癌患者中90例为TNBC,随访时间13～84个月。TNBC确诊时年龄比非TNBC(n-TNBC)患者小(P<0.01),TNBC患者确诊时肿瘤长径较n-TNBC患者肿瘤大(P<0.01)。手术时出现腋窝淋巴结转移率较高(P<0.01);TNBC中复发或转移82例,比n-TNBC患者更容易出现局部复发或远处转移(P<0.01)。TNBC比n-TNBC患者更容易发生肝、肺和脑转移(P<0.01)。TNBC组5年无病生存率和总生存率分别为3.3%和71.1%,n-TNBC组分别为4.6%和84.5%。单因素分析显示年龄、家族史、组织学分级、肿块大小、淋巴结转移数、辅助放疗及辅助内分泌治疗情况是影响TNBC与n-TNBC患者复发转移及预后的相关因素。多因素分析表明患者诊断为乳腺癌时年龄、组织学分级、肿瘤大小、腋窝淋巴结转移数均是影响TNBC患者复发转移及预后的独立影响因素。结论:与n-TNBC患者比较,TNBC发病年龄较轻,确诊时淋巴结转移率较高,术后复发转移率较高,多见于肺、肝和脑及5年总生存及无病生存率较低。

       

      Abstract: Objective:To analyze the clinical data of 90 cases with triple negative breast cancer(TNBC) in order to investigate its clinicopathologic characteristics and prognostic factors.Methods:The clinical data of 284 patients with breast cancer diagnosed by histopathology were collected.The clinicopathologic characteristics, recurrence and metastasis of TNBC were retrospectively analyzed by statistical software.Results:Among 284 breast cancer patients, 90 cases were TNBC, and were followed up for 12-84 months.The age of TNBC patient was young than that of n-TNBC patient(P<0.01), the tumor size in TNBC patient was larger than that in n-TNBC patients(P<0.01).The metastasis rate of axillary lymph node was high.The recurrence and metastasis in 82 cases of TNBC patients were found, the recurrence and distance metastasis in TNBC patients was more than that in n-TNBC patient(P<0.01).The metastases in liver, lung and brain in TNBC patients were more than those in n-TNBC patients(P<0.01).The survival analysis showed than the 5-year disease free survival and overall survival in TNBC group and n-TNBC group were 3.3% ＆ 71.1% and 4.6% ＆ 84.5%, respectively.The results of univariate analysis showed that age, family history, histological grade, tumor size, the number of lymph node metastasis, and adjuvant radio and endocrine therapy affected the recurrence, metastasis and prognosis of TNBC and n-TNBC patients.Multivariate analysis showed the age, histological grade, tumor size, the number of axillary lymph nodes metastasis were independently effective factor in the recurrence, metastasis and prognosis of TNBC patients.Conclusions:Compared with the n-TNBC patients, the TNBC patient is young, nonmenopause, high recurrence and metastasis after surgery(more in liver and bone) and low 3- and 5-year overall survival and disease free survival rates.

       

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