Abstract: Objective:To investigate the clinical effects of gamma globulin in the treatment of bronchiolitis.Methods:Seventy-six bronchiolitis children were randomly divided into the treatment group(32 cases) and control group(44 cases).The control group were treated with bronchodilators, anti-asthmetic drugs, glucorticoids, and anti- viral and infection, the treatment group were additionally treated with gamma globulin based on the conventional treatment.The time of clinical symptom disappearance and hospitalization between two groups were compared.Results:The time of clinical symptoms(including cough, pulmonary wheeze and signs) disappearance and hospitalization in treatment group were significantly shorter than those in control group(P<0.01).The total effective rate in treatment group(93.8%) was significantly higher than that in control group(79.5%)(P<0.01).Conclusions:The treatment of bronchiolitis with gamma globulima is effective and safe, which is worthy of clinical application.