Abstract: Objective:To investigate the clinical significance of high expression of synuclein gamma(SNCG) in colorectal cancer(CRC) patients with liver metastases.Methods:Two hundred and nineteen patients with CRC were divided into the liver metastasis group(114 cases) and non-liver metastasis group(105 cases).The relationships between the SNCG level identified by immunohistochemistry and liver metastasis, disease-free survival time after surgery and overall survival were analyzed.Results:The positive rates of SNCG in liver metastasis group and non-liver metastasis group were 71.96% and 28.04%, respectively.Multivariate analysis showed that the expression of SNCG in CRC patients was an independent factor of hepatic metastasis(P<0.01).The disease-free survival time after surgery and overall survival in liver metastasis patients with the positive and negative SNCG expressions were(48.70±5.40) ＆(78.75±4.23) months and(51.10±5.20) ＆(80.29±4.12) months, respectively.The survival time in negative SNCG patient was higher than that in positive SNCG patient(P<0.01).Conclusions:With the increasing of SNCG expression, the liver metastasis and disease-free survival time in CRC patients increase and shorten, respectively.High expression of SNCG in CRC tissue can be used as a prediction index of liver metastasis.