Abstract: Objective:To investigate the relationship between the dynamic change of high sensitivity C-reactive protein(hs-CRP) and prognosis in patients with acute stroke.Methods:One hundred and eighty-four patients with acute stroke were divided into the ischemic stroke group(n=102) and hemorrhagic stroke group(n=82).The levels of hs-CRP in all patients were measured before treatment and after 1, 2, 3, 4, 6 and 8 weeks of treatment.The recurrence of stroke was observed during the 1-year of following up.Results:2 patients died after onset two weeks and were removaled.The levels of hs-CRP in two groups after treatment 1 to 8 weeks compared with prior treatment all decreased significantly(P<0.01). The levels of hs-CRP after treatment 2 to 8 weeks compared with post-treatment 1 week decreased significantly too(P<0.01). The level of hs-CRP in ischemic stroke group on prior treatment and post-treatment 1 to 8 weeks compared with hemorrhagic stroke group all decreased significantly(P<0.05~P<0.01).All patients were followed up for 1 year, the recurrence rate of stroke in the patients with abnormal hs-CRP level(44.23%) was higher than that in the patients with normal hs-CRP level(11.72%)(P<0.01).Conclusions:The levels of hs-CRP in ischemic stroke group and hemorrhagic stroke group increase significantly, but the recovery of the level of hs-CRP in ischemic stroke group is more quick than that in hemorrhagic stroke group, and the recurrence rate of stroke in the patients with abnormal hs-CRP level increases.