Abstract: Objective:To evaluate the anxiety and depression status in female patients with bladder leukoplakia, and investigate its influencing factors.Methods:The anxiety and depression status in 148 female patients with bladder leukoplakia were investigated using the Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS).The gender, age, education, occupation, economic state, family history, marriage and course of the disease in all patients were analyzed.Results:The occurrence rates of anxiety and depression in 148 cases were 31.1% and 22.3%, respectively, and there was a positive correlation between anxiety and depression(P<0.01).The education, occupation, economic state and course of the disease were the risk factors of anxiety and depression(P<0.05 to P<0.01), the age, family history and marriage were not the risk factors of anxiety and depression(P>0.05).Conclusions:Anxious and depressive status are commonly found in female patients with bladder leukoplakia, which are related to the education, occupation, economic state and course of the disease.It is necessary to pay special attention and psychological intervention in the patients.