Abstract: Objective:To observe the clinical effects of propofol target controlled infusion guided by Narcotrend(NT) stages in the anesthesia of hypertension patients.Methods:Fifty 1 to 2 level primary hypertension patients treated with laparoscopic cholecystectomy were randomly divided into the observation group(group N) and control group(group C).The concentration of propofol was adjusted according to NT stages(NTS) in group N, which can maintain NTS at D2 to E0 level.The concentration of propofol in group C was adjusted according to mean arterial pressure(MAP) and HR, which can maintain MAP fluctuations at no more than ±20% of baseline and HR at 55 to 100 beats/min.The concentration of propofol in both groups were adjusted in the range of 2 to 5 μg/ml.The cardiovascular drugs were used to intervene when the MAP and HR in two groups were out of range after adjusting the depth of anesthesia.The anesthesia time, operation time, analepsia time, extubation time and dosages of propofol and sufentanil in two groups were recorded.The cardiovascular drug use and incidences of dysphoria, nausea, vomiting and intraoperative awareness in two groups were also recorded.Results:Compared with group C, the analepsia time and extubation time in group N were shortened(P<0.05 and P<0.01), and the dosage of propofol in group N decreased significantly(P<0.01).The Urapidil use in group C was more than that in group N(P<0.05).The differences of the incidences of dysphoria, nausea and vomiting between two groups were not statistically significant(P>0.05).Conclusions:The application of propofol target controlled infusion guided by NTS in the anesthesia of hypertension patients can control the anesthetic depth, maintain stable hemodynamics, shorten recovery time, conducive to the realization of accurate anesthesia, ensure the safety of anesthesia and improve the quality of anesthesia.