Abstract: Objective:To investigate the risk factors, mode of delivery, perinatal outcome, diagnosis and treatment of premature rupture of membrane in pregnancy for 28 to 36⁺⁶ weeks.Methods:The clinical data of 247 cases with pregnancy for 28 to 36⁺⁶ weeks were retrospectively analyzed.The risk factors, mode of delivery and perinatal outcome in group A(pregnancy for 28 to 31⁺⁶ weeks), group B(pregnancy for 32 to 33⁺⁶ weeks) and group C(pregnancy for 34 to 36⁺⁶ weeks) were analyzed.Results:The vaginal delivery and cesarean section rates in group A were lower and higher than those in group C, respectively(P<0.05).The incidences of neonatal respiratory distress syndrome and neonatal pneumonia in group A were significantly higher than those in group C(P<0.01).The incidence of neonatal asphyxia in group A was significantly higher than that in group B and group C(P<0.01), the differences of the neonatal respiratory distress syndrome, neonatal asphyxia and neonatal pneumonia between group B and group C were not statistically significant(P>0.05).The differences of perinatal death between 3 groups were not statistically significant(P>0.05).Conclusions:The timely diagnosis and intervention of preterm premature rupture of membrane, extending the pregnancy period and personalized assessment of perinatal outcome play an important role in improving the quality of obstetrics.