Abstract: Objective:To explore the curative effects of intravenous immunoglobulin(IVGV) in the treatment of the sever hand-foot-mouth disease(HFMD).Methods:Forty-two clildren with sever HFMD were divided into the conventional therapy group(20 cases) and immunoglobulin therapy group(22 cases).The immunoglobulin therapy group included 14 cases treated with single immunoglobulin(single therapy group) and 8 cases treated with immunoglobulin combined with methylprednisolone(combination therapy group).The curative effects between three groups were compared.Results:Compared with the conventional therapy group, the times of body temperature recovery, deflorescence and nervous system symptom improvement in the combination and single therapy groups were significantly shorter(P<0.01).The invalid or progress for the critical illness in 7 cases in the conventional therapy group, no invalid or progress case in the combination therapy group, and progress for the critical illness in 1 case in single therapy group were found.Compared with the conventional therapy group, the failed or progress case in single therapy group was less(P<0.05).Conclusions:The IVGV treatment can shorten the course and improve the prognosis of children with sever HFMD.