Abstract: Objective:To investigate the relationships between the levels of retinol binding protein 4(RBP4) and lipoprotein associated phospholipase A2(Lp-PLA2),and stability of deterioration of coronary heart disease and selective coronary angiography results.Methods:Eighty-nine patients with coronary heart disease were divided into the control group(without vessel lesion),1 vessel lesion group,2 branches lesion group and 3 branches lesion group according to the results of coronary angiography.The levels of Lp-PLA2 and RBP4 in 4 groups before angiography were detected by enzyme-linked immunosorbent assay.Results:The levels of Lp-PLA2 and RBP4 in 3 branches lesion group were significantly higher than those in control group,1 vessel lesion group and 2 branches lesion group(P<0.01).The level of Lp-PLA2 in 2 branches lesion group was significantly higher than those in control group and 1 vessel lesion group(P<0.01).The difference of the Lp-PLA2 levels between 1 branch lesion group and control group was not statistically significant(P>0.05).The difference of the RBP4 levels between 1 branch lesion group,2 branches lesion group 2 and control group were not statistically significant(P>0.05).Conclusions:The levels of serum Lp-PLA2 and RBP4 in patients with coronary heart disease are related to the number of coronary artery lesion,which can predict the stenosis degree of coronary artery in a certain extent.