Abstract: Objective:To observe the effects of the rosuvastatin combined with nicorandil in the treatment of coronary slow flow(CSF).Methods:Sixty-four patients with CSF diagnosed by coronary arteriography were randomly divided into the control group and treatment group(32 cases each group).The control group were treated with aspirin combined with rosuvastatin, the treatment group were additionally treated with nicorandil based on the control group.The improvement of chest pain and the levels of APN, TNF-α and hs-CRP in two groups after 4 and 12 weeks of treatment were measured and recorded.Results:After 4 weeks of treatment, the chest pain symptoms and levels of APN in two groups were significantly improved.The levels of APN in two groups increased significantly after 12 weeks of treatment, and the increasing degree of APN in treatment group was higher than that in control group(P<0.01).After 4 weeks of treatment, the levels of hs-CRP and TNF-α in two groups decreased.The levels of hs-CRP and TNF-α in two groups decreased significantly(P<0.01) after 12 weeks of treatment, and the decreasing degree of hs-CRP and TNF-α in treatment group was higher than those in control group(P<0.01).Conclusions:The treatment of coronary slow flow with rosuvastatin combined with nicorandil can ease the chest pain, significantly improve the level of APN and decreased the levels of hs-CRP and TNF-α of patients.