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    KDR、MC2R和PCNA在产醛固酮腺瘤与肾上腺皮质增生病变中的表达和意义

    The expressions and significance of kinase domain receptor,melanocortin-2 receptor and proliferating cell nuclear antigen in aldosterone-producing adenoma and adrenal cortical hyperplasia

      摘要
    • 摘要: 目的:探讨激酶插入区受体(KDR)、促肾上腺皮质激素受体2(MC2R)和增殖细胞核抗原(PCNA)在产醛固酮腺瘤(APA)与肾上腺皮质增生(IHA)中的表达和意义。方法:应用免疫组织化学技术检测KDR、MC2R和PCNA在APA和IHA病变组织中(各40例)的表达情况。结果:APA组织中KDR、MC2R和PCNA的阳性表达率分别为40.0%、32.5%和85.0%;IHA组织中KDR、MC2R和PCNA的阳性表达率分别为65.0%、62.5%和77.5%;2种病变组织中,KDR、MC2R和PCNA的表达强度差异均有统计学意义(P<0.05~P<0.01)。结论:KDR、MC2R和PCNA在IHA病变的发生、发展中起重要作用,对于鉴别APA和IHA病变具有重要的参考意义。

       

      Abstract: Objective:To explore the expressions and significance of kinase domain receptor(KDR), melanocortin-2 receptor(MC2R) and proliferating cell nuclear antigen(PCNA) in aldosterone-producing adenoma(APA) and adrenal cortical hyperplasia(IHA).Methods:The expressions of KDR, MC2R and PCNA in 40 cases APA and 40 cases IHA lesions were detected by immunohistochemistry.Results:The positive expression rates of KDR, MC2R and PCNA in APA lesions were 40.0%, 32.5% and 85.0%, respectively.The expression rates of KDR, MC2R and PCNA in IHA lesions were 65.0%, 62.5% and 77.5%, respectively.The differences of KDR, MC2R and PCNA expressions between APA and IHA were statistically significant(P<0.05 to P<0.01).Conclusions:The KDR, MC2R and PCNA play an important role in the occurrence and development of IHA, which have important reference meaning in the differentiation of APA and IHA lesions.

       

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