Abstract: Objective:To explore the clinical effects of vitamin B₆ through oral, intravenous infusion and acupoint injection in the treatment of pregnancy hyperemesis.Methods:Eighty-four patients with pregnancy hyperemesis were randomly divided into the group A, B and C(28 cases each group).The A, B and group C were treated with vitamin B₆ by oral, intravenous infusion and acupoint injection, respectively.The motilin levels and treatment effects in 3 groups were observed before and after treatment.Results:The total efficiency in group A(100.00%) was significantly higher than that in group B(71.43%) and group C(82.14%) after 1 week of treatment(P<0.01).The level of motilin in group C(133.53±33.16) ng/L was significantly higher than that in other two groups after treatment(P<0.01).One case with subcutaneous hemorrhage caused by short pressing time in group C was improved by himself.Conclusions:Acupoint injection of vitamin B₆ can effectively improve the motilin secretion, promote gastrointestinal motility and prevent hyperemesis gravidarum.The curative effect of vitamin B₆ is obviously superior to the oral and intravenous drip, and which is worthy of the clinical promotion.