Abstract: Objective:To investigate the clinical effects of Tanreqing injection in the treatment of pneumonia children.Methods:One hundred and seventy-six pneumonia children were randomly divided into the observation group and control group(88 cases each group).The control group were treated with antiviral, antibacterial, relieving cough and reducing sputum, the observation group were additionally treated with 0.5 ml/kg of Tanreqing injection by intravenous drip based on conventional therapy, once a day, 7 days for a course.The improvement of signs and symptoms and adverse reactions in two groups were compared after 1 course.Results:The total effective rate in the observation group(90.9%) was significantly higher than that in control group(79.5%)(P<0.01).The time of defervescence, disappearing of cough and wheezing, dyspnea remission, pulmonary rales disappearance and hospitalization in observation group were shorter than those in control group(P<0.01).The control group were small children with facial rash, other patients were no obovious adverse reactious.Conclusions:Tanreqing injection can effectively improve the clinical symptoms, significantly improve the therapeutic effect and shorten the course of disease of pneumonia children, which is safe, reliable and worthy of popularization and application.