Abstract: Objective:To analyze risk factors of lumbar infection caused by sacral canal blocking, and find corresponding preventive measures.Methods:Review cases from Jan.2006 to Jan.2014, according to analysis of rate, single factor analysis, sites, types and bacteria species, screen risk factors for lumbar infection.Results:Infection rate was 8.6%(18 in 210), among the related risk factors, the cases that over the age of 40, with diabetes mellitus, with spina bifida occulta, with cerebrospinal fluid leakage caused by puncture, and combined with more than 4 kinds of drugs injection, whose infection rates were higher than cases that below the age of 40, without diabetes mellitus, without spina bifida occulta, without cerebrospinal fluid leakage caused by puncture, and combined with less than 4 kinds of drugs injection(P<0.05 to P<0.01).The infection site located mainly in L₅~S₁ and posterior lumbar soft tissue, the infection types mainly were intervertebral infection and posterior lumbar soft tissue infection, bacteria species mainly were gram-positive cocci.Conclusions:According to analysis of risk factors of infection caused by sacral canal blocking, we can take preventive measures, to avoid infection.