Abstract: Objective: To observe the clinical effects of high flux hemodialysis in the treatment of uremic patients with chronic renal failure. Methods: One hundred and twenty uremic patients with chronic renal failure were randomly divided into the observation group and control group. The observation group and control group were treated with high flux dialysis and conventional hemodialysis, respectively. Results: The total effective rate in observation group(90.0%) was higher than that in control group after treatment(70.0%)(P<0.01). The levels of BUN, Scr, β2-MG and PTH in two groups after dialysis were significantly lower than those in before dialysis(P<0.01). BUN、β2-MG and PTH in observation group decreased significantly higher than the control group(P<0.01) after dialysis, while the Scr is oppsite(P<0.01). After dialysis, the number of cases with body mass index increasing in observation group was significantly higher than that in control group(P<0.01). and the incidence rates of bone and joint pain, fatigue and skin pruritus in observation group were lower than those in control group(P<0.05 to P<0.01). Conclusions: The treatment of uremia patients with chronic renal failure with high flux dialysis can improve the therapeutic effect, strongly clear the large, middle and small molecules, reduce the incidence rate of adverse reactions and improve the life quality of patients, which is worthy of promoting in clinic use.