Abstract: Objective: To evaluate the safety and feasibility of cardiac pacemaker combined with ultrasonic scalpel in laparoscopic cholecystectomy(LC) in patients with gallbladder calculi complicated with arrhythmia. Methods: The clinical data of 59 LC patients treated with cardiac pacemaker combined with LC were retrospectively analyzed. Results: All operations of 59 cases were successful. The drop of heart rhythm and blood pressure in one patient was found during placing pacemaker, and the patient recovered after treatment. The postoperative celialgia, icterus, palpitation and chest distress were not found in all patients, all patients cured. Conclusions: The placing cardiac pacemaker before LC in patient with gallbladder calculi complicated with arrhythmia can effectively protect the cardiac function, and reduce, time and complications of the LC.