Abstract: Objective: To investigate the clinical effects of the improved frontal sinus surgery under the nose hill guided by 0 degree mirror in the treatment of frontal sinus disease. Methods: One hundred and ten patients with frontal sinusitis were randomly divided into the observation group and control group(55 cases each group). The observation group were treated with the improved frontal sinus surgery under the nose hill guided by 0 degree mirror, the control group were treated with the conventional frontal sinus surgery. The operation condition, stress response, and short-term and long-term effects in two groups were compared. Results: The operation time and bleeding volume in observation group were less than those in control group(P<0.01), the levels of epinephrine, norepinephrine and angiotensin Ⅱ in observation group were significantly lower than those in control group(P<0.01). The short-term treatment effects and recurrence rate in observation group were significantly better and less than those in control group, respectively(P<0.05). The score of life quality in observation group was significantly higher than that in control group(P<0.01). Conclusions: The improved frontal sinus surgery under the nose hill guided by 0 degree mirror can reduce operation wound, promote postoperative recovery, relieve stress response and improve treatment effect.