Abstract: Objective: To explore the clinical effects of rosuvastatin combined with nicergoline in the treatment of cognitive impairment after carotid stenosis. Methods: One hundred and eight patients with cognitive impairment after carotid stenosis were randomly divided into the observation group(55 cases) and control group(53 cases). The control and observation group were treated with nicergoline, and rosuvastatin combined with nicergoline respectively. The cognition and activities in two groups were evaluated using the Mini Mental State Examination(MMSE)table and activities of daily living(ADL)scale, the clinical effects between two groups were compared. Results: The differences of the MMSE and ADL scores in two groups were not statistically significant before treatment(P>0.05), the MMSE and ADL scores in two groups were significantly improved(P<0.01) and the increasing degree of the MMSE and ADL scores in observation group were significantly higher than those in control group after treatment(P<0.01). The clinical total effective rate in observation group(96.36%) was significantly better than that in control group(79.25%)(P<0.01). Conclusions: The treatment of cognitive impairment after carotid stenosis with rosuvastatin combined with nicergoline can effectively improve the cognitive function and activities of daily living. The treatment effects of rosuvastatin combined with nicergoline is significantly better than that of nicergoline, which is worthy of application in clinical.